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Image courtesy of StarfaceBest Alcohol-Free Spot Treatment
Innbeauty Project Pimple Paste
Best Alcohol-Free Spot Treatment
Innbeauty Project Pimple Paste
Credit: Innbeauty ProjectPros
- Transfer-proof
Cons
- Best used overnight
Here's a fast-acting spot treatment that combines willow bark, sulfur, tea tree oil, azelaic acid, and more to fight breakouts and blemishes as you sleep. Its formula is also designed to stay put—even through tossing and turning—which means you don't have to worry about the paste staining your sheets or pillowcase.
One satisfied customer writes: "Oh my goodness, I have been using this pimple paste for the last few weeks and have truly noticed a difference in my skin, in love!!!" —Julianna M.
| Key ingredients: | Willow bark, sulfur, tea tree oil, azelaic acid, clay, zinc, oregano, and thyme |
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Most Popular Spot Treatment
Mario Badescu Drying Lotion
Most Popular Spot Treatment
Mario Badescu Drying Lotion
Credit: AmazonPros
- Works quickly
Cons
- May be irritating for sensitive skin
There's a reason over 31,000 shoppers are raving about this pink drying lotion from Mario Badescu: It combines acne-fighting ingredients like salicylic acid and sulfur to get rid of zits overnight.
One satisfied customer writes: "This stuff is great. No shaking. Dip the Q-Tip to the pink and dab. Sleep. Wash off in the morning. Watch your face look amazing." —Kay A.
| Key ingredients: | Calamine, camphor, sulfur, zinc oxide, salicylic acid |
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Best Spot Treatment for Oil Control
Payot Pate Grise Anti-Blemish Spot Treatment
Best Spot Treatment for Oil Control
Payot Pate Grise Anti-Blemish Spot Treatment
Credit: PayotPros
- Made from 97% natural ingredients
Cons
- May stain sheets
A little goes a long way when it comes to this spot treatment. Mattifying clay is the star in Payot's top-rated formula, working to control excess oil while also reducing the size of breakouts. Plus, it's not only dermatologist-tested, but also non-comedogenic and paraben-free.
One satisfied customer writes: "I like the airy texture with green clay and tea tree scent! Also easy to remove in the morning." —Alex
| Key ingredients: | Lactobacillus lysate probiotic, meadowsweet, glycolic and lactic acid, organic tea tree essential oil, zinc oxide |
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Best Benzoyl Peroxide Spot Treatment
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream
Best Benzoyl Peroxide Spot Treatment
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream
Credit: AmazonPros
- Safe for sensitive skin
When it comes to the acne spot treatment he most typically recommends to his clients, Hartman reaches for this popular option from La Roche-Posay. "I recommend La-Roche Posay Effaclar Duo Acne Treatment, which uses micronized benzoyl peroxide to penetrate deeper into the skin to clear active acne," he adds.
| Key ingredients: | Benzoyl peroxide, beta-lipohydroxy acid |
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Best Plant-Based Spot Treatment
Kinship Pimple Potion Retinal + Salicylic Acne Treatment
Best Plant-Based Spot Treatment
Kinship Pimple Potion Retinal + Salicylic Acne Treatment
Credit: CredoPros
- Gentle
As a beauty enthusiast, I've tried my fair share of spot treatments over the years, but this one from Kinship is one I gravitate back to again and again. Not only does it work quickly to minimize pimples, but it also can be used on the entire face if you're dealing with a particularly bad breakout.
One satisfied customer writes: "I started using this a week ago and it really helps. It doesn’t dry my skin out, and reduces the look of a zit by the next day. I don’t feel a burn or anything when putting it on, but still does the job—it’s very gentle! Quickly absorbs too so you could apply makeup after, etc." —Elizabeth
| Key ingredients: | Retinal, bakuchiol, salicylic acid, plant-based probiotics |
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Best Anti-Aging Spot Treatment
SkinCeuticals Blemish + Age Defense Salicylic Acid Acne Treatment
Best Anti-Aging Spot Treatment
SkinCeuticals Blemish + Age Defense Salicylic Acid Acne Treatment
Credit: DermstorePros
- Reduce the appearance of fine lines
Cons
- Best for mature skin
This top-rated serum can be used as a spot treatment to minimize acne while improving the appearance of fine lines and hyperpigmentation at the same time.
One satisfied customer writes: "I recently added this to my SkinCeuticals routine and love it. I am 41, and have cystic acne on my chin and it has cleared up completely!" —Rebecca
| Key ingredients: | Alpha hydroxy acids, glycolic acid, salicylic acid |
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Best Redness Reducing Spot Treatment
Tula Go Away Acne Spot Treatment
Best Redness Reducing Spot Treatment
Tula Go Away Acne Spot Treatment
Credit: UltaPros
- Works quickly
The name of this popular treatment says it all: Not only is it powered by benzoyl peroxide to quickly fight breakouts, but it also uses ingredients like niacinamide, azelaic acid, and tea tree oil to soothe redness and irritation.
One satisfied customer writes: "I'm actually in awe of this product. I had some hormonal blemishes on my face and I used this product twice a day for two days. The pimples were raised, irritated and red at first, now three days later, they are essentially gone!! I'm seriously amazed. I've tried other acne spot treatments and none have ever worked this well." —Riley G.
| Key ingredients: | Probiotic extracts, benzoyl peroxide, tea tree oil, licorice, niacinamide |
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Best Hydrocolloid Spot Treatment
Starface Hydro-Stars + Big Yellow
Best Hydrocolloid Spot Treatment
Starface Hydro-Stars + Big Yellow
Credit: StarfacePros
- Mess-free
For a set it and forget it option for acne, reach for these fun hydrocolloid patches from Starface. These stickers work overtime to shrink zits while protecting them from the elements. I love using them in my nighttime routine for ultimate beauty rest.
One satisfied customer writes: "They work great! I noticed a visible difference after using the Hydro-Stars. Also the packaging is super cute and convenient. Highly recommend!" —Jenn W.
Best Spot Treatment That Doubles as a Mask
Sunday Riley Saturn Sulfur Spot Treatment
Best Spot Treatment That Doubles as a Mask
Sunday Riley Saturn Sulfur Spot Treatment
Credit: UltaPros
- Great for stubborn breakouts
Cons
- May be too intensive for sensitive skin
Whether you decide to use this treatment in dabs or all over your face, your breakouts are no match for its powerful sulfur formula.
One satisfied customer writes: "I am completely obsessed with many of Sunday Riley’s products, and this is one of them. It's hands down the most effective spot blemish treatment I have used. I put a dab of the green cream on the blemish, leave it on over night, and within 24 hours it's significantly dried up. Decreases redness. The sulfur smell is not my favorite, but the product does the job." —shadowmoonbeam
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Best Value Spot Treatment
Neutrogena On-The-Spot Acne Spot Treatment
Best Value Spot Treatment
Neutrogena On-The-Spot Acne Spot Treatment
Now 39% Off
Credit: AmazonPros
- Budget-friendly
We count Neutrogena's On-The-Spot Acne Spot Treatment as one of the OG pimple fighters. Its effective benzoyl peroxide formula absorbs quickly, and doesn't leave skin feeling dry once its applied.
One satisfied customer writes: "Pimples are visibly better after just one application. Got this for my teenager. He loves it too." —Tan X.
| Key ingredients: | Benzoyl peroxide |
|---|---|
| Color | White |
Best Spot Treatment Device
SolaWave Bye Acne: 3-Minute Pimple Spot Treatment
Best Spot Treatment Device
SolaWave Bye Acne: 3-Minute Pimple Spot Treatment
Now 30% Off
Credit: SolaWavePros
- Mess-free
Cons
- Can only be used once on each targeted area per day
I previously tested SolaWave's Bye Acne: 3-Minute Pimple Spot Treatment, which combines blue and red light technology to minimize zits in a literal flash. It's an easy-to-use tool that's perfect for managing random acne flare-ups, whether you're at home or on the go.
One satisfied customer writes: "I’ve been using the device for a few weeks now and it is so good for getting rid of breakouts. It’s not a bad price for a light therapy device and it’s totally worth it!!" —Cait
Best Spot Treatment for Oily Skin
Dr Dennis Gross DRx Blemish Solutions Acne Eliminating Gel
Best Spot Treatment for Oily Skin
Dr Dennis Gross DRx Blemish Solutions Acne Eliminating Gel
Credit: DermstorePros
- Contains niacinamide to reduce redness
Cons
- May be too intensive for sensitive skin
This beloved gel uses a combination of two percent salicylic acid, retinol, and glycolic acid to fight acne, and also happens to work as an astringent to help control oil production.
One satisfied customer writes: "This product is the best when it comes to pimples. As soon as I get one, I put this on and it’s gone the next day. This product is excellent! And a must to have in your toiletries." —Sheriann
| Key ingredients: | Alpha hydroxy acids, glycolic acid, salicylic acid, niacinamide |
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Best Spot Treatment for Whiteheads
First Aid Beauty Pharma BHA Acne Spot Treatment Gel
Best Spot Treatment for Whiteheads
First Aid Beauty Pharma BHA Acne Spot Treatment Gel
Credit: DermstorePros
- Contains aloe and oatmeal to soothe irritation
If you tend to develop whiteheads in addition to acne, this top-rated treatment gel from First Aid Beauty might be next up on your holy-grail skincare list. It uses two types of salicylic acid—two percent of the ingredient, along with its natural derivative, willow bark extract—to quickly clear your complexion.
One satisfied customer writes: "Works well! Helps cut break out time in half or better." —Felicia
| Key ingredients: | Salicylic acid, glycolic acid, papaya, willow bark extract |
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Best Fast-Acting Spot Treatment
Murad Rapid Relief Acne Spot Treatment
Best Fast-Acting Spot Treatment
Murad Rapid Relief Acne Spot Treatment
Credit: MuradPros
- Invisible
Murad's hardworking spot treatment aims to minimize breakouts in four hours, and features a clear formula that won't stick out like a sore thumb under your foundation and concealer.
One satisfied customer writes: "This product is great. Applied at night and by morning, redness was gone. Blemishes reduced immensely. Highly recommend." —Shauna
| Key ingredients: | Salicylic acid, pine and thyme-inspired complex, horse chestnut, oat |
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Best Spot Treatment for Blackheads
The Inkey List Succinic Acid Acne Treatment
Best Spot Treatment for Blackheads
The Inkey List Succinic Acid Acne Treatment
Credit: The Inkey ListPros
- Vegan
This treatment uses a blend of succinic and salicylic acids plus sulfur powder to not only get rid of existing acne, but also helps prevent future breakouts from occurring. And since it also features hyaluronic acid, it'll leave your skin looking and feeling just a bit plumper.
One satisfied customer writes: "I will definitely buy this again, it really works. I put a small amount on bumps and blemishes before bed and they are definitely smaller in the morning. And they heal more quickly." —Franx
| Key ingredients: | Succinic acid, sulfur powder, salicylic acid, hyaluronic acid |
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Best Overnight Spot Treatment
Renée Rouleau Night Time Spot Lotion
Best Overnight Spot Treatment
Renée Rouleau Night Time Spot Lotion
Credit: Renée RouleauPros
- Ideal for face and body breakouts
Cons
- Can only be used at night
Here's a nighttime spot lotion from Renée Rouleau that works while you sleep to fight acne and whiteheads. As an added bonus, it can even be used to treat backne and chest breakouts.
One satisfied customer writes: "Best lotion to dry unwanted pimples I have ever used." –Carol E.
Best Salicylic Acid Spot Treatment
Beautycounter Countercontrol SOS Acne Spot Treatment
Best Salicylic Acid Spot Treatment
Beautycounter Countercontrol SOS Acne Spot Treatment
Credit: BeautycounterPros
- Top-rated
This treatment gel exclusively uses maximum strength salicylic acid to target unwanted breakouts, and also contains a wintergreen and rosebay willow complex that helps keep skin balanced.
One satisfied customer writes: "I’ve struggled with stress acne that pops up after a long hard day of work, and putting this on before bed wipes them out the next day without drying me out!" —Nikki M.
| Key ingredients: | Salicylic acid, wintergreen, and rosebay willow |
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Meet the Experts
- Corey L. Hartman, M.D., F.A.A.D, is the founder of Skin Wellness Dermatology in Birmingham, Alabama.
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When in your routine should an acne spot treatment be applied?
Spot treatments can be applied during either your morning or evening skin routines, but many beauty enthusiasts most commonly use them in the daytime. "I personally use a spot treatment after applying moisturizer, but before applying sunscreen," Hartman says. "You can also spot treat right before applying moisturizer and sunscreen."
What are some red flags that an acne spot treatment is too intense?
According to Hartman, some clear indicators that a product may not be ideal for you are, "If your skin feels uncomfortable—too tight, painful, or tender to the touch—or is dry and flakey, your spot treatment may be too intense," he advises. "You can try using less of the spot treatment, or space out the times per week you use it, or try and entirely different product. Your board-certified dermatologist can help make recommendations on products and frequency of use, too."
Tiffany Dodson is currently the associate beauty commerce editor at Harper’s Bazaar, where she specializes in trend forecasting, building relationships with major and emerging brands, and crafting shopping stories—from holiday gift guides to product road tests. Tiffany's work has previously been featured in outlets like SELF, Bustle, and Teen Vogue, and she's been quoted as a commerce and beauty expert in publications and platforms like The Business of Fashion and NPR’s Life Kit podcast.
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